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They comprised 13 genotype 1 samples (including 7 subtype 1a, 5 subtype 1b and 1 subtype 1e), 2 genotype 2 samples (including 1 subtype 2a and 1 subtype 2 l), 4 genotype 3a samples, 3 genotype 4 samples (including 1 subtype 4b et 2 subtype 4r), 1 genotype 5a sample and 1 recombinant 2k/1b strain
In the absence of insulin, PI3K is inactive, so the FOXO homolog daf-16 is able to translocate to the nucleus and turn on many genetic pathways associated with longevity in the roundworm Caenorhabditis elegans
shorter durations of use may also be protective
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