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10.1155/2022/3063899 Summary Keywords bloodbrain barrier damage, botanical drug, high-altitude cerebral edema, hypoxia, Tibetan medicine, traditional Chinese medicine Citation Gao Y, Luo Y, Chen L, Mi E, He Z, Shang B, Sui S and Zheng W (2026) Therapeutic advances in traditional Chinese and Tibetan medicine for high-altitude cerebral edema

Abstract Animals rely on nervous systems to cope with environmental variability, whereas plants are characterized by lack of nervous system but still have evolved systemic communication systems through signaling molecules that trigger long-distance defense signaling events when encountered with environmental challenges

Notably, human studies show that exercise itself boosts MOTS-c levels

Engeset, A., Olszewski, W., Jaeger, P