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When to contact your GP or diabetes specialist nurse: If you've been taking expired Rybelsus and notice worsening blood glucose control If you experience unexplained symptoms such as persistent thirst, increased urination, or fatigue If you're unable to obtain a fresh supply of your medication For advice on alternative diabetes management strategies if Rybelsus is temporarily unavailable Seek urgent medical advice (call NHS 111) or emergency care (999) if you experience: Severe dehydration (extreme thirst, dry mouth, little or no urination) Confusion or drowsiness Rapid breathing Severe abdominal pain or persistent vomiting Very high blood glucose levels that don't respond to usual treatment These could be signs of severe hyperglycaemia or hyperosmolar hyperglycaemic state (HHS), which requires immediate medical attention

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GLP-1RAs can reduce the IL-6/STAT3 signaling pathway and enhance the cytotoxicity of NK and CD8 + T cells, potentially promoting the elimination of cancer cells ( + T cells ( + T cell experiment, for which a few similar studies have shown the same result, can be further explored by using additional markers to distinguish the smaller groups of T cells and observe their apoptosis ratio ( 7 Comparison with other drugs Some clinical studies have used other metabolic medications and compared their effects on liver diseases to those of GLP-1RAs