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The side effects might be either due to high dose of vitamin B12 or allergic reaction to its composition

In 2017, the International Diabetes Federation estimated that there were 451 million patients with diabetes and 374 million people with impaired glucose tolerance worldwide (Cho et al., 2018)

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Multiple mechanisms contribute to this close relationship, including 18,19 : Endothelial dysfunction Volume overload and salt retention Overactivity of the sympathetic (fight-or-flight) nervous system Adverse changes in the hormonal regulation of blood pressure Dysfunction of the renin-angiotensin-aldosterone system Ultimately, in people with CKD and diabetes, kidney tissue and blood vessels are much more sensitive to pressure damage than those with uncomplicated mild-to-moderate high blood pressure