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In these contexts, it was proposed that NCC may act as a receptor for interleukin 18 (IL-18), potentially collaborating with receptors for the incretin glucagon-like peptide 1 (GLP-1) to enhance -cell mass and help maintain glucose homeostasis (Zhang et al., 2022b)

Briggs WA, Pedersen MM, Mahajan SK, Sillix DH, Prasad AS, McDonald FD

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Hypoglycemia risk requires special attention if you take tirzepatide with insulin or sulfonylureas