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In published preclinical work, Ipamorelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or aldosterone, which separates it from earlier secretagogues like GHRP-2 and GHRP-6.nnOriginally developed by Novo Nordisk in the mid-1990s as NNC 26-0161, it was studied in Phase 2 trials for postoperative ileus before that program was discontinued