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The dual mechanism produces additive or combined effects on energy balance -- GIPR activation in the CNS may enhance the anorectic signals from GLP-1R activation, and peripheral GIPR signaling improves adipose tissue function and lipid handling in ways GLP-1 alone does not

Combining semaglutide with protein-rich foods and regular movement can help maintain muscle mass during weight loss

Patients taking higher doses may be more likely to experience leg cramps, as the medications effects on blood sugar and body fluids are stronger at these levels

Staying hydrated is equally important for supporting metabolism and curbing hunger