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The activation of FGFR1c by intracellular phosphate results in increased expression of the GALNT3 gene which encodes the enzyme, N -acetylgalactosaminyltransferase 3

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PMID 15209499

Mitochondrial injury in AP is accompanied by decreased m, elevated ROS levels, activation of the NLRP3 inflammasome, and pyroptosis, ultimately leading to PAC necrosis ( This interaction is likely to be especially important in HTG-AP, in which overwhelming delivery of triglyceride-derived non-esterified fatty acids (NEFAs) creates a lipotoxic environment that exceeds the oxidative capacity of a single organelle system