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IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns

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doi: 10.2174/0929867329666221005111553

Benzodiazepines directly bind GABA receptors, producing sedation, amnesia, physical dependence, and withdrawal risk