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Targeting metabolic adaptation of colorectal cancer with vanadium-doped nanosystem to enhance chemotherapy and immunotherapy

The MTHFR gene directs the production of an enzyme by the same name

Five domains are in composition of this protein: N-terminal domains Phox and Bem1p (PB1), zinc finger domain of ZZ-type, PEST site (containing presumed phosphorylation sites), and C-terminal domain binding polyubiquitin (UBA)

Inhibition of Apoc1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-Pd1 immunotherapy in hepatocellular carcinoma based on single-cell Rna sequencing