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doi:10.1016/j.jogoh.2017.07.004

This region requires more caution due to the presence of significant blood vessels

Rectal glutathione delivery eliminates digestive tract and liver metabolism losses, providing 40%-50% more bioavailability through rectal vasculature

Specifically, electroacupuncture downregulates histone deacetylase 2, promoting microbial homeostasis and reducing the abundance of pro-inflammatory taxa, ultimately mitigating neuroinflammation and alleviating pain and depressive-like behaviors in chronic stress models (Li et al., 2024)