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doi: 10.1124/dmd.113.053546
PIP3 recruits and activates Akt (also called protein kinase B), a master regulatory kinase that phosphorylates dozens of downstream substrates to promote anabolism and cell survival
To enhance the pharmacological properties of the ruthenium catalyst, provide cancer selectivity for the treatment, and enable the treatment of challenging hypoxic tumors, the metal complexes were covalently conjugated to the side chains of polymers with a carbon fluorinated moiety that could co-deliver oxygen to the tumor
(2020) 16:e1008629
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