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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

Key Features: GHK-Cu Peptide: Supports skin hydration and appearance

In hippocampal neurons, this same pathway induces BDNF expression, suggesting potential neurotrophic and metabolic roles during development

Later meta-analyses also report small but significant reductions in body weight, BMI or fat mass, with effects more relevant in overweight or obese populations