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A crossover study operated on 30 human healthy subjects (380), showed a slight increase in plasmatic GLP-1 and a slight decrease in ghrelin levels 30 min after a Capsaicin enriched meal (containing 1,030 mg of 80,000 Scoville heat units red pepper)

If true, it means brain health benefits

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After GLP-1 weight loss, the body often tries to defend its previous weight through increased hunger, metabolic adaptation, lower energy expenditure, and weight-regain biology