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92 Phosphorylation and activation of AMPK is in response to nutrients and AMP/ATP ratio through the upstream kinases serine/threonine kinase (LKB1) and calcium/calmodulin-dependent protein kinase (CaMKK)

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Moreover, NADPH binding induced local conformational changes in the N-terminal long loop (residues 3459) of Pa DHDPR, as the His35 and Lys36 residues in this loop interacted with the 2-phosphate group of NADPH, possibly accounting for the strong preference of Pa DHDPR for NADPH