Glutathione depletion impacts the gamma glutamyl cycle in the liver by increasing the activity of -glutamyl cysteine synthetase and accumulation of -glutamyl cysteine, which is converted by -glutamyl cyclotransferase to pyroglutamic acid/5-oxyproline [3, 4] (Fig
As a classic m6A reader protein, YTHDF1 enhances the translation efficiency of specific transcripts (75), and previous studies have reported its involvement in regulating the expression of genes related to ferroptosis (76)
An acute inflammatory response is associated with several signs including redness, swelling, pain, heat, and loss of function
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