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Several alternative therapeutic strategies have been investigated, including protein kinase C inhibitors [10], darbepoetin alfa [11], endothelin receptor antagonists (ERAs) [12], direct renin inhibitors [13], nuclear factor erythroid 2-related factor 2 activators [14], and combination of ACE inhibitor and ARB [15]

Despite numerous studies during the past decades, cell-extrinsic and -intrinsic molecular mechanisms governing the dynamic metabolic changes in hepatocytes after partial hepatectomy (PH) still remain incompletely understood

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