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Vero cells were treated with different concentrations of compounds with DMSO as control and incubated in the presence of 5% CO 2 at 37 C for 24 h

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

Furthermore, metformin has the potential to modulate glucose-lipid metabolism (GLM) to mitigate oxidative stress, suppress inflammatory reactions, shield cells from oxidative damage, and enhance the fertility of the endometrium

Be gentle and patientit pays off