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High-Density Lipoprotein (HDL): HDL is known as good cholesterol

GLP-1RAs can effectively improve some key pathophysiological defects of T2DM, which has been proved to have significant hypoglycemic and weight-loss effects, and can reduce the major adverse cardiovascular events in adult patients with type 2 diabetes with cardiovascular disease [6], so it has become an important choice for the treatment of T2DM

Recent studies have shown that these medications, such as Ozempic and Wegovy, are highly effective for weight loss in non-diabetic patients as well

As a result of that, initial recommendations focus on the use of metformin or a thiazolidinedione if metformin is contraindicated, followed by a GLP-1 agonist or a DPP-4 inhibitor