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The cortisol response to food is also enhanced in obese subjects compared to normal BMI individuals (222)

Vogel, J., Cinatl, J., Dauletbaev, N., et al

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In other words, IGF-LR3 was originally used as a way to break through a fat loss or muscle gain plateau, with the idea that one could spend weeks at the same weight and fitness level without the use of exogenous IGF-LR3 supplementation, but if a cycle of IGF-LR3 was added, the body suddenly gets sparked into anabolic action again