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With tirzepatide dose escalation extending to 15mg and semaglutide to 2.4mg weekly, clinicians in 2025-2026 have increasingly noted that reduced food intake at higher doses can compound electrolyte losses particularly sodium and magnesium which are direct headache triggers

If you use exogenous insulin, its like 1iu, maybe 2, for maximum benefit

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While you should always have a hypoglycemia action plan in place and glucose products like shots, tablets, and gels on hand, taking prescribed GLP-1 receptor agonists can help to provide peace of mind, knowing the medication is supporting the release of insulin when levels are high