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Additionally, her hyperphagia was quite severe, and medications with stronger mechanisms for appetite regulation (like GLP-1 RAs) were ultimately more impactful. Despite extensive evaluation for monogenic and syndromic causes of hyperphagia, a clear diagnosis was not reached

After research demonstrated that people could lose up to 11% of their body weight from Ozempic, it skyrocketed in popularity as an off-label medication for weight loss

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Aligned with earlier findings, semaglutide treatment at dosages from 0.5 mg to 2 mg weekly demonstrated variable efficacy, from merely preventing further weight gain in Patient 1 to achieving weight loss of up to 14.4% and 11% relative to baseline, in Patient 2 and Patient 3, respectively