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Scheduling and combination strategies that maintain pressure on ectopic cells while preserving antioxidant capacity in nonlesional compartments warrant systematic evaluation, supported by pharmacokineticpharmacodynamic mapping and biomarker programs that verify on-lesion lipid peroxidation and redox modulation while monitoring marrow, hepatic, renal, and mitochondrial safety

TMAO in Gut-Brain Axis The gut-brain axis has progressively become a research hotspot