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Significant reductions in serum levels of total IS, p-CS, IL-6, and malondialdehyde (as markers of inflammation and oxidative stress, respectively) were observed in 30 patients with ESKD undergoing hemodialysis treatment after an 8-week administration of synbiotics containing 2 10 11 (CFU)/g of Lactobacillus acidophilus La-14 and FOS (Kuskunov et al., 2023)

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Fourth, there are regulatory gaps in oversight

According to the International Diabetes Federation (IDF) in 2021, approximately 537 million adults aged 2079 worldwide have diabetes, which is expected to rise to 783 million by 2045 (Ogurtsova et al., 2022)