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Clinical Evidence and Safety Data on Combining These Treatments No major randomized controlled trial has exclusively studied semaglutide combined with HRT, but large-scale GLP-1 trials (including SUSTAIN and SELECT) have enrolled women on various hormone therapies without identifying safety signals

Effects of GLP-1RA on Kidney Outcomes in CKD Studies The FLOW-CKD trial examined the benefits of semaglutide compared to a placebo in patients with diabetes and CKD, specifically focusing on long-term kidney outcomes (Table 2)

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Research has also shown that body weight loss, especially in men, can lead to higher testosterone levels