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22 Variations in formulation, dosing schedules, and dual agonism with tirzepatide influence tolerability, emphasizing the need for individualized therapy

Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

The safety and efficacy of this other insulin glargine product administered pre-breakfast or at bedtime were also evaluated in a randomized, active-controlled clinical study (Study I, n=697) in patients with type 2 diabetes not adequately controlled on oral anti-diabetic therapy

Second, there was heterogeneity among the included studies in terms of treatment duration, characteristics of the study population, and medication doses