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Reassess at intervals If you are feeling no effect even after several weeks, reconsider whether to continue the medication

Most of these studies have suggested clinically relevant reductions in migraine frequency and severity, but are limited by lack of placebo control (four out of seven studies)

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Diabetes Obes Metab 22(12):24872492 Verma S, Bhatta M, Davies M, Deanfield JE, Garvey WT, Jensen C, et al (2023) Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): Exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials