6.3.2 Insulin modulation HA represents the endocrine hallmark of PCOS, sustained mainly by hyperinsulinemia, OS, and disrupted steroidogenic signaling (228)
Dysregulated glucose metabolism can also contribute to hypertension by promoting insulin resistance, which activates the sympathetic nervous system and increases norepinephrine secretion, further inducing vasoconstriction and raising blood pressure [258,259,260]
Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available
Coordinating with different interviewees, including pharmacists and customers, was no small feat