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On the other hand, PGC-1/NRF1 regulates FUNDC1-mediated mitophagy through transcription, promoting mitochondrial biogenesis during the process of mitochondrial autophagy, accelerating mitochondrial turnover, and maintaining normal mitochondrial respiration and mitochondrial population stability

We propose that this interference by metformin may be enhanced in individuals with the A allele in the cubilin gene, though mechanistic investigations are needed to prove this