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Common period changes after starting tirzepatide While menstrual changes are not listed as a side effect of tirzepatide, some people report: Irregular or delayed periods Lighter or heavier flow Spotting between cycles Missed periods during rapid weight loss Cycles that take several months to normalize Remember, tirzepatide doesnt directly cause menstrual changes

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Constipation is already common in people with an underactive thyroid, and adding a medication that delays gastric emptying can worsen symptoms