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Several case series (55, 56) and open-label trials (5760) suggest that the combination of a better glycemic control, improved metabolic parameters and bodyweight reductions achieved by exenatide treatment as monotherapy or as add-on to standard therapies may lead to improvements in liver biomarkers and hepatic fat reductions in patients with T2D

Vitamin B6 Requiring Reactions Pyridoxal phosphate (PLP) functions as a cofactor in all of the enzymes that carry out the transamination (aminotransferase) reactions required for the synthesis and catabolism of the amino acids

Table 2 Clinical evidence of GLP-1R agonists for treating DPN

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