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In the IVD, melatonin diminished cellular apoptosis caused by tert-butyl hydroperoxide, maintained ECM production, and suppressed the expression of degenerative enzymes, including MMP-13 and ADAMTS-5, in NP cells

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In this context, such effect biomarkers are recognized as an ideal tool for investigating the relationships between exposure to environmental chemical and adverse health outcomes in population-based studies, as well as for elucidating some of the mechanisms underlying these associations 6,10,24