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Experimental design The study was a double-blinded randomized parallel control trial examining the effect of 30 g/day inulin (Synergy1,Orafti, Tienen, Belgium) versus the control cellulose (Vitacel Powdered Cellulose L 60020, J
Figure 1 Ketogenesis might be another potential mechanism reducing GLP-1 secretion induced by a high-fat diet, as found by culturing primary intestinal endocrine cells in mice, where ketone bodies can inhibit approximately 40% of basal GLP-1 secretion ( A ketogenic diet (KD) is formulated with a high fat proportion and low carbohydrate proportion and is designed to induce ketogenesis
Both have decades of clinical use behind them, which provides a level of evidence that newer peptides like Dihexa and P21 have not yet achieved despite their promising preclinical results
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