Currie BJ, Harumal P, McKinnon M, Walton SF
Its pathophysiology involves multiple interconnected mechanisms, including monoaminergic neurotransmitter depletion, impaired neurotrophic signaling, neuroinflammation accompanied by hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and glutamate-induced excitotoxicity (Medeir et al., 2020)
Semaglutide, originally developed for diabetes management, showed significant weight loss results in both clinical trials and real-world settings, which attracted widespread adoption
Where once Rybelsus stood alone as the only GLP-1 pill available, patients and clinicians must now navigate three distinct oral products, each with a different molecule, a different approved indication, and a different set of practical requirements