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While the benefits of single antioxidant therapy may be limited and may even have negative effects, for example, long-term use of beta-carotene may increase the incidence of lung cancer in smokers (60), while vitamin E may increase the risk of bleeding in people with oral anticoagulants and even reduce the lipid-lowering effect of statins (61), Therefore, the safety and efficacy of long-term additional oral antioxidants deserve further exploration

doi:10.1161/CIRCOUTCOMES.113.000663

Ishimi Y, Sugiyama F, Ezaki J, Fujioka M, Wu J (2006) Effects of spirulina, a blue-green alga, on bone metabolism in ovariectomized rats and hindlimb-unloaded mice

Liftd Cortisol: As noted, transient increases can occur, especially with higher doses