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Enhanced drug delivery For combination therapy, microneedling creates temporary channels through the stratum corneum (skin barrier), allowing topical treatments to penetrate 510 deeper into the follicle than surface application

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By conjugating nanomaterials with ligands that recognize these unique bacterial markers, researchers can ensure that the nanomaterials selectively bind to and disrupt harmful bacteria without affecting healthy microorganisms

Natural products such as asiatic acid (123), total ginsenosides, ursolic acid (124), dillapiole (125) and notoginsenoside R1 (126) can activate PPAR and regulate FA levels, as detailed in Table 1