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2018;7:e009379

Alitalo, K

In the mITT population, the average change in the number of SSEs from baseline to the end of the study was +0.7 events per month in the pooled groups receiving 1.25 and 1.75 mg doses of BMT, compared to only +0.2 events in the placebo group

Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)