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The Nobel Prize in Physics 2024

The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]

Short Half-Life, Targeted Potency Unlike IGF1 LR3 , which has a long half-life (2030 hours) and systemic activity, IGFDES has a shorter half-life (2030 minutes) but an intense localized effect

Vascular Klotho defi-ciency potentiates the development of human artery calcification and mediates re-sistance to fibroblast growth factor 23