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Vasodilation provides up to 25 -50 times resting levels of local blood flow by means of relaxation of the smooth arterial musculature and of the sphincter allowing flow into the capillary bed [9]

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114 ABCB4 and ABCB11 gene mutations have not been studied in isolated communities such as Inuit or Amish groups, but there is evidence of a significantly increased presence of ABC transporter-related liver disease in ATP8B1 deficiency, likely due to founder mutations, which result in high-frequency genetic alterations from a small ancestral cohort