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doi: 10.1016/j.immuni.2021.09.005 162 CheongJESunL

This process is morphologically marked by small mitochondria with condensed membrane densities, and biochemically by iron overload and GSH depletion, leading to loss of antioxidant defense and irreversible oxidative damage ( 3.2 Key molecular drivers of ferroptosis Iron Overload: Excess intracellular ferrous iron (Fe 2+ ) catalyzes the Fenton reaction, producing hydroxyl radicals (OH) that initiate lipid peroxidation cascades

Nabi, K., & Le, A

These models address the limitations of OHE, managing dimensionality issues and enhancing the interpretability of diagnostic patterns within ICD-10 and medication codes