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Ca 2+ overload, which is a crucial event in eryptosis, leads to the opening of Ca 2+ -activated K + channel KCa3.1, known as the Gardos channel [90]

Increased intracellular calcium inhibits enzymes responsible for the distribution of phospholipids in plasma membranes and the release of cytochrome C and apoptosis-inducing factors, triggering neuronal apoptotic death, suppressing neurotransmission, and cognitive dysfunction (Bezprozvanny and Mattson 2018)

Implications for regeneration and neurodegenerative diseases

It activates amylin receptors 1 and 3 (AMY1R/AMY3R) heterodimers of the calcitonin receptor with receptor activity-modifying proteins (Lau et al., 2021)