Holotranscobalamin (active B12) where available, this is a more sensitive early marker of B12 depletion and may be preferred in some settings [12] [15] Full blood count to identify macrocytosis or anaemia Folate levels as folate deficiency can co-exist and confound the clinical picture Methylmalonic acid (MMA) and homocysteine functional markers of B12 status, useful when serum B12 is borderline
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Patients who took GLP-1 agonists for diabetes and weight loss experienced improvements in depressive symptoms, although the patients in those trials did not have clinical depression
However, the pen must never be exposed to temperatures above 30C or direct sunlight, as excessive heat can denature the protein structure of semaglutide, rendering it ineffective
