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Eventually, an estimated 6 million Americans took fenfluramine or dexfenfluramine, most of them women, not all of them obese. It had been on the market for two years after doctors discovered the medication could cause heart valve defects in a third of patients
It has been shown that Akkermansia protects the intestinal barrier by increasing the expression of occludin and zona occludens protein 1, thereby preventing lipopolysaccharide translocation, reducing metabolic endotoxemia-induced inflammation, and attenuating atherosclerotic lesions (Li et al., 2016)
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic beta cells
Bibcode:1998JAFC...46..206W
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