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In 1996, the first detection of this biomarker of oxidative stress was proposed for plasma in patients with chronic uremia (77)

People with a prior history of gastrointestinal problems and aged individuals are more likely to suffer from intense stomach cramps and severe diarrhoea after taking high doses of vitamin B. Most people are able to get enough vitamin B12 from their diets, however, occasionally when running low, supplements or B12 injections may be recommended

PMID: 7 ZafarAKhatoonSKhanMJAbuJNaeemA

In that case, these supplements can be a great maintenance option to extend and preserve your results at a fraction of the cost