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The TPO receptor agonist regulates blood platelet production by binding to and activating TPO receptors on megakaryocyte cells and inducing signalling cascades that increase platelet production

While MS is not a contraindication to semaglutide therapy, careful consideration of the medication's adverse effect profile, potential drug interactions with disease-modifying therapies, and individual patient factors is essential

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In view of a clear Vit B12 deficiency and/or HHcy and/or high MMA levels in a PwPD presetting with clinical signs of PN, a complete neurographic assessment and an extensive alternative-causes workup should be performed