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QTL significance threshold During QTL genome scan, each locus is tested by comparing the model in Equation 3 to one excluding the locus term using a logarithm of odds (LOD) score statistic, roughly analogous to a likelihood ratio

MEDI0382, a GLP/glucagon receptor dual agonist, significantly reduces hepatic fat content in subjects with type 2 diabetes mellitus

28 LOLA is a combination of endogenous amino acids that are metabolized in periportal and perivenous hepatocytes, where L-ornithine is utilized as a substrate in the urea cycle and acts as an activator of carbamoyl phosphate synthetase, the rate limiting enzyme of the urea cycle