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Liver and Adipose Similar to the studies done looking at pancreatic insulin production, both CDDO-Im administration and Keap1 knockdown in diabetic mice ( db/db:Keap1 FA/ ) resulted in an NRF2-dependent increase in hepatic production of fibroblast growth factor 21 ( Fgf21 ), which in turn influenced carbohydrate metabolism (i.e., expression of Glut1 and Hk2 ) in adipose tissue and decreased plasma triglyceride levels (108)

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Benign Thyroid Conditions Conditions such as hypothyroidism, Hashimotos thyroiditis, Graves disease, and non-cancerous goitres are generally not contraindications