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These findings highlight the therapeutic versatility of GLP-1RAs, addressing inflammatory conditions from the CNS to the anterior segment of the eye

CPT1A can also protect cells from apoptosis by clearing the cytoplasmic long-chain fatty acyl-CoA such as palmitoyl-CoA, and thus impede the production of palmitate/palmitoyl-CoA/ceramide involved in the apoptosis pathway activation 31

The procedure is performed under ultrasound guidance to ensure accuracy of needle placement

For the brain, where the same mechanism operates, this results from a rise of intracellular calcium concentration, [Ca 2+ ], triggering pericyte contraction during ischaemia, with subsequent pericyte dysfunction or death maintaining the constriction when the arterial blood supply is restored 9