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The measurement of the carotid intima-media thickness (CIMT) is a surrogate endpoint for early atherosclerosis and a predictor for cardiovascular events (106)

Another example is a study that reported Curcumin Encapsulated Lipidic Nanoconstructs (CLEN) achieving an approximately 1.4-million-fold increase in aqueous solubility and about a 70-fold improvement in oral bioavailability compared to free curcumin (40)

Mechanistic studies indicate that some metabolites from probiotics downregulate hypha- and adhesion-associated genes (HWP1), disrupt membrane integrity, acidify the microenvironment, and interfere with quorum sensing and matrix production (Ribeiro et al., 2017)

Dysregulated autophagy contributes to retinal diseases