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pylori: Helicobacter pylori DOX: Doxorubicin CPCs: colloidal photonic crystals MRI: Magnetic resonance imaging FI: Fluorescence imaging PLGA: Poly (lactic-co-glycolic acid) PDA: Polydopamine IgG: Immunoglobulin PPI: Proton pump inhibitors ROS: Reactive oxygen species CT: Computed tomography IBD: Inflammatory bowel disease IL6: Interleukin-6 MNP: Macrophage membrane coated nanoparticle BCTN: Bio-chemotaxis-guided self-thermophoretic nanoplatform CRC: Colorectal cancer TME: Tumor microenvironment T1D: Type 1 diabetes T2D: Type 2 diabetes PC: Pancreatic cancer References Kiela PR, Ghishan FK

The development of procaine in 1904 did not solve the problem of systemic toxicity, and the Committee for the Study of Toxic Effects of Local Anesthetics published a report of 43 fatal cases linked to the use of LAs